From the north BAB A5/E4:
direction Basel, exit: Frankfurt Westkreuz / A 648
direction Wiesbaden, exit: Frankfurt-Rödelheim

From the east BAB A66:
direction Wiesbaden, exit: Eschborner Dreieck / A648 direction Messe (fair), exit: Frankfurt Rödelheim

From the south BAB A5/E4:
direction Kassel, exit: Frankfurt Westkreuz / A648 direction Wiesbaden, exit: Frankfurt-Rödelheim

From the west BAB A66:
direction Frankfurt Messe (fair) / A648 direction Basel: exit: Frankfurt-Rödelheim